Cerilliant, Round Rock, Tex, has introduced four Certified Spiking Solutions of the corticosteroids pregnenolone, 17?-hydroxypregnenolone, cortisone, and 11-deoxycorticosterone at concentrations of 100 ?g/mL in methanol. These hormones have been shown to serve as biomarkers of pain and as indicators of abnormal hormone production. While the analysis of hormones and other small molecules for neonatal screening by LC-MS/MS is well established, pain management clinics are increasingly using LC-MS/MS methods to quantify pregnenolone, 17?- hydroxypregnenolone, cortisone, and other hormones in patient serum. Suitable for preparation of calibrators, controls, and linearity standards, the spiking solutions offer laboratories improved efficiency of labor and convenience of use. For more information, visit Cerilliant.