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Multi-Pathogen Diagnostics Critical for Accurately Diagnosing Infectious DiseasesSeegene, Rockville, Md, made public the results of several clinical studies seeking to measure the rate of accurately diagnosing sexually transmitted diseases (STDs) and respiratory virus (RV) infections. The studies carried out in Korea and Japan compared conventional single-pathogen tests against Seegene’s simultaneous multipathogen test systems. The results effectively conclude that conventional testing regimens relying on single pathogen tests leave a high percentage of patient infections undiagnosed. From a pool of 903 respiratory patient samples, 72% tested positive for a RV infection when monitored by Seegene’s 12-plex multi-RV detection system. Using a conventional single RV detection system those same 903 patient samples yielded only a 5% positive infection rate of influenza A, 8% for influenza B, 16% of Respiratory Syncytial Virus (RSV) A, and 14% of RSV B. From a pool of 673 STD patient samples, Seegene’s 6-plex multi-STD detection system yielded an STD infection rate of 81%, and a co-infection (two or more pathogens) rate of 24%. With conventional routine testing for Chlamydia trachomatis and Neisseria gonorrhoeae, only 16% and 5% of the respective infections were detected. At the recent 11th Asian Pacific Congress of Clinical Biochemistry (APCCB), Dr. Chang-Seok Ki of Samsung Medical Center and Sungkyunkwan University School of Medicine in Seoul, Korea, who performed the RV study said, “The Seeplex multiplex-PCR assay is a viable alternative to conventional VC/IF-based test methods, making it a suitable diagnostic modality for respiratory disease.” Ki added, “Additionally, the Seeplex system achieves its sensitivity within 24 hours compared to a viral culture can take up to a week. Our data suggests that Seeplex tests will help reduce the incidence of nosocomial transmission to high risk patients, and improve the clinical management through the use of appropriate and directed treatment after diagnosis." Seegene recently announced its Seeplex 18-plex Respiratory Pathogen Test, which detects 11 different respiratory RNA viruses, 2 DNA viruses, and 5 pneumonia bacteria from samples including nasopharyngeal aspirates, nasopharyngeal swabs and bronchoalveolar lavage. Seeplex tests are based on Dual Priming Oligo (DPO) for blocking extension of non-specific primed templates, thereby generating consistently high PCR specificity even under less than optimal PCR conditions. 
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