Pyrazinamide (PZA) susceptibility testing is now available for M. tuberculosis on the BacTec MGIT 960 Systems. The availability of PZA now makes it possible to test all of the drugs that are used as first line therapy to treat M. tuberculosis.
     The BacTec MGIT 960 PZA Kit is a 4 to 21 day qualitative test, designed to monitor the growth of M. tuberculosis in a drug-containing tube compared to a drug-free tube (growth control). The PZA medium, containing modified Middlebrook 7H9 broth, is in a tube containing a fluorescent compound. The BacTec MGIT 960 instrument continually monitors tubes for increased fluorescence, indicating the presence of active microorganisms. Susceptible or resistant results are produced when the instrument compares the drug-containing tube to the growth control tube.
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Keywords: susceptibility, automation